Reaction Details Report a problem with these data
Target
Apoptosis regulator BAX
Ligand
BDBM50547487
Substrate
n/a
Meas. Tech.
ChEMBL_2018355 (CHEMBL4671933)
EC50
725±n/a nM
Citation
 Liang, T; Zhou, Y; Elhassan, RM; Hou, X; Yang, X; Fang, H HDAC-Bax Multiple Ligands Enhance Bax-Dependent Apoptosis in HeLa Cells. J Med Chem 63:12083-12099 (2020) [PubMed]  Article 
Target
Name:
Apoptosis regulator BAX
Synonyms:
Apoptosis regulator BAX | BAX | BAX_HUMAN | BCL2L4 | Bcl-2-like protein 4 | Bcl2-L-4
Type:
PROTEIN
Mol. Mass.:
21181.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100916
Residue:
192
Sequence:
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
  
Inhibitor
Name:
BDBM50547487
Synonyms:
CHEMBL4761391
Type:
Small organic molecule
Emp. Form.:
C25H21N7O4S2
Mol. Mass.:
547.609
SMILES:
ONC(=O)CCCOc1ccc(cc1)-c1csc(n1)N1N=C(\C(=N\Nc2nccs2)C1=O)c1ccccc1 |c:22|
Structure:
Search PDB for entries with ligand similarity: