Reaction Details Report a problem with these data
Target
Apoptosis regulator BAX
Ligand
BDBM50547494
Substrate
n/a
Meas. Tech.
ChEMBL_2018359 (CHEMBL4671937)
IC50
3300±n/a nM
Citation
 Liang, T; Zhou, Y; Elhassan, RM; Hou, X; Yang, X; Fang, H HDAC-Bax Multiple Ligands Enhance Bax-Dependent Apoptosis in HeLa Cells. J Med Chem 63:12083-12099 (2020) [PubMed]  Article 
Target
Name:
Apoptosis regulator BAX
Synonyms:
Apoptosis regulator BAX | BAX | BAX_HUMAN | BCL2L4 | Bcl-2-like protein 4 | Bcl2-L-4
Type:
PROTEIN
Mol. Mass.:
21181.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100916
Residue:
192
Sequence:
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLSECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
  
Inhibitor
Name:
BDBM50547494
Synonyms:
CHEMBL4783072
Type:
Small organic molecule
Emp. Form.:
C21H19N5O2S
Mol. Mass.:
405.473
SMILES:
CCOc1ccccc1N\N=C1\C(C)=NN(C1=O)c1ncc(s1)-c1ccccc1 |c:14|
Structure:
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