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Target
Aspartyl/asparaginyl beta-hydroxylase
Ligand
BDBM25150
Substrate
n/a
Meas. Tech.
ChEMBL_2018812 (CHEMBL4672390)
IC50
3100±n/a nM
Citation
 Brewitz, L; Tumber, A; Zhang, X; Schofield, CJ Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-?-hydroxylase. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Aspartyl/asparaginyl beta-hydroxylase
Synonyms:
1.14.11.16 | ASP beta-hydroxylase | ASPH | ASPH_HUMAN | Aspartate beta-hydroxylase | Aspartyl/asparaginyl beta-hydroxylase | BAH | Peptide-aspartate beta-dioxygenase
Type:
PROTEIN
Mol. Mass.:
85823.27
Organism:
Homo sapiens
Description:
ChEMBL_120098
Residue:
758
Sequence:
MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHVEGEDLQQEDGPTGEPQQEDDEFLMATDVDDRFETLEPEVSHEETEHSYHVEETVSQDCNQDMEEMMSEQENPDSSEPVVEDERLHHDTDDVTYQVYEEQAVYEPLENEGIEITEVTAPPEDNPVEDSQVIVEEVSIFPVEEQQEVPPETNRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEAVNAFKELVRKYPQSPRARYGKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADLLKLSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEEVLSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPKETGYTELVKSLERNWKLIRDEGLAVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETKTWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI
  
Inhibitor
Name:
BDBM25150
Synonyms:
(2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide | Belinosta | Belinostat | PXD-101 | PXD101
Type:
Small organic molecule
Emp. Form.:
C15H14N2O4S
Mol. Mass.:
318.348
SMILES:
ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1
Structure:
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