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Target
Aldo-keto reductase family 1 member B7
Ligand
BDBM50547656
Substrate
n/a
Meas. Tech.
ChEMBL_2018933 (CHEMBL4672511)
IC50
4498±n/a nM
Citation
 Chen, H; Zhang, X; Zhang, X; Fan, Z; Liu, W; Lei, Y; Zhu, C; Ma, B Dihydrobenzoxazinone derivatives as aldose reductase inhibitors with antioxidant activity. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B7
Synonyms:
ALD1_RAT | Akr1b14 | Akr1b7 | Aldehyde reductase | Aldo-keto reductase family 1 member B7 | Aldose reductase-like protein AKR1B14 | Aldose reductase-related protein 1
Type:
PROTEIN
Mol. Mass.:
36127.39
Organism:
Rattus norvegicus
Description:
ChEMBL_109605
Residue:
316
Sequence:
MTTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQEKIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKEFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAKHKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACGLFVTSDEEDFPFHEEY
  
Inhibitor
Name:
BDBM50547656
Synonyms:
CHEMBL4759527
Type:
Small organic molecule
Emp. Form.:
C19H17NO6
Mol. Mass.:
355.3414
SMILES:
COc1cc(\C=C\c2cccc3N(CC(O)=O)CC(=O)Oc23)ccc1O
Structure:
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