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Target
Insulin-like growth factor-binding protein 3
Ligand
BDBM50106441
Substrate
n/a
Meas. Tech.
ChEMBL_90405 (CHEMBL698360)
Ki
29±n/a nM
Citation
 Chen, C; Zhu, YF; Liu, XJ; Lu, ZX; Xie, Q; Ling, N Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. J Med Chem 44:4001-10 (2001) [PubMed]  Article 
Target
Name:
Insulin-like growth factor-binding protein 3
Synonyms:
IBP3 | IBP3_HUMAN | IGFBP3 | Insulin-like growth factor binding protein 3
Type:
PROTEIN
Mol. Mass.:
31690.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_90404
Residue:
291
Sequence:
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
  
Inhibitor
Name:
BDBM50106441
Synonyms:
1-(3,4-Dihydroxy-benzyl)-isoquinoline-3,6,7-triol | CHEMBL336069
Type:
Small organic molecule
Emp. Form.:
C16H13NO5
Mol. Mass.:
299.2781
SMILES:
Oc1ccc(Cc2[nH]c(=O)cc3cc(O)c(O)cc23)cc1O
Structure:
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