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Target
Insulin-like growth factor-binding protein 1
Ligand
BDBM50106432
Substrate
n/a
Meas. Tech.
ChEMBL_90401 (CHEMBL698356)
Ki
34±n/a nM
Citation
 Chen, C; Zhu, YF; Liu, XJ; Lu, ZX; Xie, Q; Ling, N Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. J Med Chem 44:4001-10 (2001) [PubMed]  Article 
Target
Name:
Insulin-like growth factor-binding protein 1
Synonyms:
IBP1 | IBP1_HUMAN | IGFBP1 | Insulin-like growth factor binding protein 1
Type:
PROTEIN
Mol. Mass.:
27896.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_90401
Residue:
259
Sequence:
MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN
  
Inhibitor
Name:
BDBM50106432
Synonyms:
(3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinolin-1-yl)-methanone | CHEMBL130994
Type:
Small organic molecule
Emp. Form.:
C16H11NO6
Mol. Mass.:
313.2616
SMILES:
Oc1ccc(cc1O)C(=O)c1[nH]c(=O)cc2cc(O)c(O)cc12
Structure:
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