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Target
Insulin-like growth factor-binding protein 1
Ligand
BDBM50106431
Substrate
n/a
Meas. Tech.
ChEMBL_90401 (CHEMBL698356)
Ki
5.1±n/a nM
Citation
 Chen, C; Zhu, YF; Liu, XJ; Lu, ZX; Xie, Q; Ling, N Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. J Med Chem 44:4001-10 (2001) [PubMed]  Article 
Target
Name:
Insulin-like growth factor-binding protein 1
Synonyms:
IBP1 | IBP1_HUMAN | IGFBP1 | Insulin-like growth factor binding protein 1
Type:
PROTEIN
Mol. Mass.:
27896.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_90401
Residue:
259
Sequence:
MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN
  
Inhibitor
Name:
BDBM50106431
Synonyms:
1-(3,4-Dihydroxy-benzoyl)-6,7-dihydroxy-isoquinoline-3-carboxylic acid | CHEMBL292700
Type:
Small organic molecule
Emp. Form.:
C17H11NO7
Mol. Mass.:
341.2717
SMILES:
OC(=O)c1cc2cc(O)c(O)cc2c(n1)C(=O)c1ccc(O)c(O)c1
Structure:
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