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Target
Glutamate carboxypeptidase 2
Ligand
BDBM17659
Substrate
n/a
Meas. Tech.
ChEMBL_141138 (CHEMBL749038)
IC50
0.3±n/a nM
Citation
 Jackson, PF; Tays, KL; Maclin, KM; Ko, YS; Li, W; Vitharana, D; Tsukamoto, T; Stoermer, D; Lu, XC; Wozniak, K; Slusher, BS Design and pharmacological activity of phosphinic acid based NAALADase inhibitors. J Med Chem 44:4170-5 (2001) [PubMed]  Article 
Target
Name:
Glutamate carboxypeptidase 2
Synonyms:
FOLH1_RAT | Folh1 | Glutamate carboxypeptidase II | Naalad1
Type:
PROTEIN
Mol. Mass.:
84547.28
Organism:
Rattus norvegicus
Description:
ChEMBL_68365
Residue:
752
Sequence:
MWNAQQDSDSAEALGRRQRWFCAGTLVLAFTGTFIIGFLFGWFIKPSNDSTSSVSYPGMKKAFLQELKAENIKKFLYNFTRTPHLAGTQHNFELAKQIHAQWKEFGLDLVELSDYDVLLSYPNKTHPNYISIINEDGNEIFKTSLAELSPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLERVMKINCSGKIVIARYGQVFRGNKVKNAQLAGAKGIILYSDPADYFVPGVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEYAYRHEFTEAVGLPSIPVHPIGYDDAQKLLEHMGGSAPPDSSWKGGLKVPYNVGPGFAGNFSKQKVKLHIHSYNKVTRIYNVIGTLKGAVEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRTFGTLKKKGWRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMHSLVYNLTKELPSPDEGFEGKSLYDSWKEKSPSTEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKNNKVSSYPLYHSVYETYELVEKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKHAETIYNISMNHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQDLDKSNPILLRILNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDINNKVDTSKAWREVKRQISIAAFTVQAAAETLREVD
  
Inhibitor
Name:
BDBM17659
Synonyms:
(R,S)-2-phosphonomethylpentanedioic acid | 2-(phosphonomethyl)pentanedioic acid | 2-PMPA | CHEMBL47009 | US10894807, ID P009 | pentanedioic acid analogue, (RS)-1
Type:
Small organic molecule
Emp. Form.:
C6H11O7P
Mol. Mass.:
226.1211
SMILES:
OC(=O)CCC(CP(O)(O)=O)C(O)=O
Structure:
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