Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50107095
Substrate
n/a
Meas. Tech.
ChEBML_88617
IC50
2100±n/a nM
Citation
 Dupont, R; Jeanson, L; Mouscadet, JF; Cotelle, P Synthesis and HIV-1 integrase inhibitory activities of catechol and bis-catechol derivatives. Bioorg Med Chem Lett 11:3175-8 (2001) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50107095
Synonyms:
6-(3,4-Dihydroxy-phenyl)-naphthalene-2,3-diol | 6-(3,4-dihydroxyphenyl)naphthalene-2,3-diol | CHEMBL108672
Type:
Small organic molecule
Emp. Form.:
C16H12O4
Mol. Mass.:
268.2641
SMILES:
Oc1ccc(cc1O)-c1ccc2cc(O)c(O)cc2c1
Structure:
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