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Target
T-cell surface glycoprotein CD4
Ligand
BDBM50548978
Substrate
n/a
Meas. Tech.
ChEMBL_2023579 (CHEMBL4677392)
IC50
740±n/a nM
Citation
 Lumangtad, LA; Claeys, E; Hamal, S; Intasiri, A; Basrai, C; Yen-Pon, E; Beenfeldt, D; Vermeire, K; Bell, TW Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
T-cell surface glycoprotein CD4
Synonyms:
CD4 | CD4_HUMAN | CD_antigen=CD4 | T-cell surface antigen CD4 | T-cell surface antigen T4/Leu-3 | T-cell surface glycoprotein CD4
Type:
PROTEIN
Mol. Mass.:
51136.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_440402
Residue:
458
Sequence:
MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
  
Inhibitor
Name:
BDBM50548978
Synonyms:
CHEMBL4748787
Type:
Small organic molecule
Emp. Form.:
C33H36ClN3O4S2
Mol. Mass.:
638.24
SMILES:
Cl.Cc1ccc(cc1)S(=O)(=O)N1CCc2cc(cc(CCN(CC(=C)C1)S(=O)(=O)c1ccc(C)cc1)n2)-c1ccccc1
Structure:
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