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Target
GTPase KRas
Ligand
BDBM50549221
Substrate
n/a
Meas. Tech.
ChEMBL_2024068 (CHEMBL4677881)
EC50
320±n/a nM
Citation
 Chen, H; Smaill, JB; Liu, T; Ding, K; Lu, X Small-Molecule Inhibitors Directly Targeting KRAS as Anticancer Therapeutics. J Med Chem 63:14404-14424 (2020) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50549221
Synonyms:
CHEMBL4293433
Type:
Small organic molecule
Emp. Form.:
C15H17ClIN3O3
Mol. Mass.:
449.671
SMILES:
Oc1cc(Cl)c(I)cc1NCC(=O)N1CCN(CC1)C(=O)C=C
Structure:
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