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Target
GTPase KRas
Ligand
BDBM50436053
Substrate
n/a
Meas. Tech.
ChEMBL_2024074 (CHEMBL4677887)
EC50
15800±n/a nM
Citation
 Chen, H; Smaill, JB; Liu, T; Ding, K; Lu, X Small-Molecule Inhibitors Directly Targeting KRAS as Anticancer Therapeutics. J Med Chem 63:14404-14424 (2020) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50436053
Synonyms:
CHEMBL2396992
Type:
Small organic molecule
Emp. Form.:
C11H12Cl2N2
Mol. Mass.:
243.132
SMILES:
Cc1[nH]c2cc(Cl)cc(Cl)c2c1CCN
Structure:
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