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Target
Fibroblast growth factor 23
Ligand
BDBM50549236
Substrate
n/a
Meas. Tech.
ChEMBL_2024190 (CHEMBL4678003)
IC50
2790±n/a nM
Citation
 Downs, RP; Xiao, Z; Ikedionwu, MO; Cleveland, JW; Lin Chin, A; Cafferty, AE; Darryl Quarles, L; Carrick, JD Design and development of FGF-23 antagonists: Definition of the pharmacophore and initial structure-activity relationships probed by synthetic analogues. Bioorg Med Chem 29:0 (2021) [PubMed]  Article 
Target
Name:
Fibroblast growth factor 23
Synonyms:
FGF-23 | FGF23 | FGF23_HUMAN | Fibroblast growth factor 23 | Fibroblast growth factor 23 C-terminal peptide | Fibroblast growth factor 23 N-terminal peptide | HYPF | HYPF | Phosphatonin | Tumor-derived hypophosphatemia-inducing factor
Type:
PROTEIN
Mol. Mass.:
27966.65
Organism:
Homo sapiens
Description:
ChEMBL_115874
Residue:
251
Sequence:
MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTGPEGCRPFAKFI
  
Inhibitor
Name:
BDBM50549236
Synonyms:
CHEMBL4754240
Type:
Small organic molecule
Emp. Form.:
C16H21NO
Mol. Mass.:
243.344
SMILES:
CC(C)(C)c1ccc(cc1)C1=C(CCC1)\C=N\O |t:11|
Structure:
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