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Target
Sorbitol dehydrogenase
Ligand
BDBM50108738
Substrate
n/a
Meas. Tech.
ChEMBL_201003 (CHEMBL801253)
IC50
40±n/a nM
Citation
 Chu-Moyer, MY; Ballinger, WE; Beebe, DA; Berger, R; Coutcher, JB; Day, WW; Li, J; Mylari, BL; Oates, PJ; Weekly, RM Orally-effective, long-acting sorbitol dehydrogenase inhibitors: synthesis, structure-activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines. J Med Chem 45:511-28 (2002) [PubMed]  Article 
Target
Name:
Sorbitol dehydrogenase
Synonyms:
DHSO_HUMAN | L-iditol 2-dehydrogenase | SORD
Type:
PROTEIN
Mol. Mass.:
38332.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_223910
Residue:
357
Sequence:
MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
  
Inhibitor
Name:
BDBM50108738
Synonyms:
1-(4-{4-[2-(2-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazin-1-yl}-pyrimidin-2-yl)-ethanol | CHEMBL149981
Type:
Small organic molecule
Emp. Form.:
C16H22N6O2
Mol. Mass.:
330.3849
SMILES:
C[C@@H](O)c1nccc(n1)N1CCN(CC1)c1ccnc(CCO)n1
Structure:
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