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Target
Kynurenine 3-monooxygenase
Ligand
BDBM50549707
Substrate
n/a
Meas. Tech.
ChEMBL_2025623 (CHEMBL4679436)
IC50
1.7±n/a nM
Citation
 Kimura, H; Suda, H; Kassai, M; Endo, M; Deai, Y; Yahata, M; Miyajima, M; Isobe, Y N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors. Bioorg Med Chem Lett 33:0 (2021) [PubMed]  Article 
Target
Name:
Kynurenine 3-monooxygenase
Synonyms:
KMO_MOUSE | Kmo | Kynurenine 3-hydroxylase | Kynurenine 3-monooxygenase
Type:
PROTEIN
Mol. Mass.:
54550.12
Organism:
Mus musculus
Description:
ChEMBL_109577
Residue:
479
Sequence:
MASSDTQGKRVAVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVAKSARGRSINLALSYRGRQALKAIGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISRENLNKDLLTAVESYANAKVHFGHKLSKCIPEEGVLTVLGPDKVPRDVTCDLVVGCDGAYSTVRAHLMKKPRFDYTQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAYMMIALPNMDKSFTCTLFMPFEEFERLPTRSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSHCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNNLSMCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQKLLDKFLHAIMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLIAIGGTYLLVHHLSLRPLEFLRRPAWMGTTGYWTRSTDISLQVPWSY
  
Inhibitor
Name:
BDBM50549707
Synonyms:
CHEMBL4781856
Type:
Small organic molecule
Emp. Form.:
C21H22N4O2S
Mol. Mass.:
394.49
SMILES:
Cc1ccc(cc1)S(=O)(=O)Nc1ccc(nn1)-c1ccccc1N1CCCC1
Structure:
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