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Target
Kynureninase
Ligand
BDBM50109155
Substrate
n/a
Meas. Tech.
ChEBML_91728
Ki
130±n/a nM
Citation
 Walsh, HA; Leslie, PL; O'Shea, KC; Botting, NP 2-Amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid; a potent inhibitor of rat and recombinant human kynureninase. Bioorg Med Chem Lett 12:361-3 (2002) [PubMed]  Article 
Target
Name:
Kynureninase
Synonyms:
KYNU_RAT | Kynu
Type:
PROTEIN
Mol. Mass.:
52470.50
Organism:
Rattus norvegicus
Description:
ChEMBL_91725
Residue:
464
Sequence:
MEPSPLELPVDAVRRIATELNCDPTDERVALRLDEEDKLKRFKDCFYIPKMRDLPSIDLSLVNEDDNAIYFLGNSLGLQPKMVKTYLEEELDKWAKIGAYGHEVGKRPWIIGDESIVSLMKDIVGAHEKEIALMNALTVNLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLHGLDVEKSMRMIKPREGEETLRMEDILEVIEKEGDSIAVVLFSGLHFYTGQLFNIPAITQAGHAKGCFVGFDLAHAVGNVELHLHDWDVDFACWCSYKYLNSGAGGLAGAFIHEKHAHTIKPALVGWFGHELSTRFNMDNKLQLIPGVNGFRISNPPILLVCSLHASLEIFQQATMTALRRKSILLTGYLEYLLKHYHGGNDTENKRPVVNIITPSRAEERGCQLTLTFSISKKGVFKELEKRGVVCDKREPEGIRVAPVPLYNSFHDVYKFIRLLTAILDSTERN
  
Inhibitor
Name:
BDBM50109155
Synonyms:
2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric acid | 2-amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid | CHEMBL120534
Type:
Small organic molecule
Emp. Form.:
C10H13NO4
Mol. Mass.:
211.2145
SMILES:
NC(CC(O)c1cccc(O)c1)C(O)=O
Structure:
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