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Target
Kynureninase
Ligand
BDBM50109155
Substrate
n/a
Meas. Tech.
ChEMBL_91723 (CHEMBL702021)
Ki
100±n/a nM
Citation
 Walsh, HA; Leslie, PL; O'Shea, KC; Botting, NP 2-Amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid; a potent inhibitor of rat and recombinant human kynureninase. Bioorg Med Chem Lett 12:361-3 (2002) [PubMed]  Article 
Target
Name:
Kynureninase
Synonyms:
KYNU | KYNU_HUMAN | L-kynurenine hydrolase
Type:
PROTEIN
Mol. Mass.:
52356.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_91729
Residue:
465
Sequence:
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN
  
Inhibitor
Name:
BDBM50109155
Synonyms:
2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric acid | 2-amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid | CHEMBL120534
Type:
Small organic molecule
Emp. Form.:
C10H13NO4
Mol. Mass.:
211.2145
SMILES:
NC(CC(O)c1cccc(O)c1)C(O)=O
Structure:
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