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Target
Protein arginine N-methyltransferase 8
Ligand
BDBM50550091
Substrate
n/a
Meas. Tech.
ChEMBL_2026419 (CHEMBL4680577)
IC50
8200±n/a nM
Citation
 Qian, K; Yan, C; Su, H; Dang, T; Zhou, B; Wang, Z; Zhao, X; Ivanov, I; Ho, MC; Zheng, YG Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases. RSC Med Chem 12:95-102 (2021) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 8
Synonyms:
ANM8_HUMAN | HRMT1L3 | HRMT1L3 | HRMT1L4 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4 | PRMT8 | Protein arginine N-methyltransferase 8 | Protein arginine N-methyltransferase 8 (PRMT8) | Protein arginine methyltransferase 8 (PRMT8)
Type:
Protein
Mol. Mass.:
45293.70
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
394
Sequence:
MGMKHSSRCLLLRRKMAENAAESTEVNSPPSQPPQPVVPAKPVQCVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDNIITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDRAALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIKEVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTHWKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYKMR
  
Inhibitor
Name:
BDBM50550091
Synonyms:
CHEMBL4648477
Type:
Small organic molecule
Emp. Form.:
C22H20N6
Mol. Mass.:
368.4344
SMILES:
NC(=N)c1ccc(Nc2ccc(cc2)-c2cc3ccc(cc3[nH]2)C(N)=N)cc1
Structure:
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