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Target
Histone deacetylase 3
Ligand
BDBM476609
Substrate
n/a
Meas. Tech.
ChEMBL_2027199 (CHEMBL4681357)
IC50
>10000±n/a nM
Citation
 McClure, JJ; Zhang, C; Inks, ES; Peterson, YK; Li, J; Chou, CJ Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia. J Med Chem 59:9942-9959 (2016) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM476609
Synonyms:
N-(4-(2-isopropylhydrazine-1- carbonyl)benzyl)benzamide | US10870618, Compound 2b
Type:
Small organic molecule
Emp. Form.:
C18H21N3O2
Mol. Mass.:
311.3782
SMILES:
CC(C)NNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1
Structure:
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