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Target
Muscle, skeletal receptor tyrosine-protein kinase
Ligand
BDBM50550246
Substrate
n/a
Meas. Tech.
ChEMBL_2027271 (CHEMBL4681429)
IC50
53±n/a nM
Citation
 Skerratt, SE; Andrews, M; Bagal, SK; Bilsland, J; Brown, D; Bungay, PJ; Cole, S; Gibson, KR; Jones, R; Morao, I; Nedderman, A; Omoto, K; Robinson, C; Ryckmans, T; Skinner, K; Stupple, P; Waldron, G The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain. J Med Chem 59:10084-10099 (2016) [PubMed]  Article 
Target
Name:
Muscle, skeletal receptor tyrosine-protein kinase
Synonyms:
MUSK | MUSK_HUMAN | Muscle, skeletal receptor tyrosine protein kinase
Type:
PROTEIN
Mol. Mass.:
97062.85
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1474077
Residue:
869
Sequence:
MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGTVSV
  
Inhibitor
Name:
BDBM50550246
Synonyms:
PF06273340 | Pf-06273340
Type:
Small organic molecule
Emp. Form.:
C23H22ClN7O3
Mol. Mass.:
479.919
SMILES:
CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(Cl)cn3)c2)c2cnc(N)nc12
Structure:
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