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Target
Estrogen-related receptor gamma
Ligand
BDBM485047
Substrate
n/a
Meas. Tech.
ChEMBL_2027414 (CHEMBL4681572)
IC50
20±n/a nM
Citation
 Kim, J; Woo, SY; Im, CY; Yoo, EK; Lee, S; Kim, HJ; Hwang, HJ; Cho, JH; Lee, WS; Yoon, H; Kim, S; Kwon, OB; Hwang, H; Kim, KH; Jeon, JH; Singh, TD; Kim, SW; Hwang, SY; Choi, HS; Lee, IK; Kim, SH; Jeon, YH; Chin, J; Cho, SJ Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor ? (ERR?) Inverse Agonists. J Med Chem 59:10209-10227 (2016) [PubMed]  Article 
Target
Name:
Estrogen-related receptor gamma
Synonyms:
ERR gamma-2 | ERR3 | ERR3_HUMAN | ERRG2 | ESRRG | Estrogen receptor-related protein 3 | Estrogen-Related Receptor, gamma | Estrogen-related receptor gamma | KIAA0832 | NR3B3 | Nuclear receptor subfamily 3 group B member 3
Type:
PROTEIN
Mol. Mass.:
51305.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1501351
Residue:
458
Sequence:
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
  
Inhibitor
Name:
BDBM485047
Synonyms:
US10934303, Cmpd No. 6g | US10934303, Example 10 | US10934303, Example 11 | US10934303, Example 7 | US11285226, Compound 6g
Type:
Small organic molecule
Emp. Form.:
C30H35NO3
Mol. Mass.:
457.6038
SMILES:
CN1CCCC1CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1
Structure:
Search PDB for entries with ligand similarity: