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Target
DNA (cytosine-5)-methyltransferase 3B
Ligand
BDBM50550751
Substrate
n/a
Meas. Tech.
ChEMBL_2028445 (CHEMBL4682603)
EC50
5300±n/a nM
Citation
 Pechalrieu, D; Dauzonne, D; Arimondo, PB; Lopez, M Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells. Eur J Med Chem 186:0 (2020) [PubMed]  Article 
Target
Name:
DNA (cytosine-5)-methyltransferase 3B
Synonyms:
DNM3B_HUMAN | DNMT3B
Type:
PROTEIN
Mol. Mass.:
95771.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1473708
Residue:
853
Sequence:
MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREVSSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPSPRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGTPQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRKAMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKSKVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
  
Inhibitor
Name:
BDBM50550751
Synonyms:
CHEMBL4748200
Type:
Small organic molecule
Emp. Form.:
C16H11BrN2O7
Mol. Mass.:
423.172
SMILES:
COc1ccc(c(c1)[C@H]1Oc2ccccc2C(=O)[C@]1(Br)[N+]([O-])=O)[N+]([O-])=O |r|
Structure:
Search PDB for entries with ligand similarity: