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Target
Protein disulfide-isomerase A3
Ligand
BDBM50550837
Substrate
n/a
Meas. Tech.
ChEMBL_2028620 (CHEMBL4682778)
IC50
16500±n/a nM
Citation
 Robinson, RM; Reyes, L; Duncan, RM; Bian, H; Strobel, ED; Hyman, SL; Reitz, AB; Dolloff, NG Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor. Eur J Med Chem 186:0 (2020) [PubMed]  Article 
Target
Name:
Protein disulfide-isomerase A3
Synonyms:
5.3.4.1 | 58 kDa glucose-regulated protein | 58 kDa microsomal protein | Disulfide isomerase ER-60 | ER protein 57 | ER protein 60 | ERP57 | ERP60 | Endoplasmic reticulum resident protein 57 | Endoplasmic reticulum resident protein 60 | GRP58 | PDIA3 | PDIA3_HUMAN | Protein disulfide-isomerase A3 | p58
Type:
PROTEIN
Mol. Mass.:
56780.19
Organism:
Homo sapiens
Description:
ChEMBL_118246
Residue:
505
Sequence:
MRLRRLALFPGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEYDDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLESTAGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQEEKPKKKKKAQEDL
  
Inhibitor
Name:
BDBM50550837
Synonyms:
CHEMBL4762045
Type:
Small organic molecule
Emp. Form.:
C18H19F3O2
Mol. Mass.:
324.3375
SMILES:
CCCCCC\C=C1/C=C(c2cc3OCOc3cc12)C(F)(F)F |c:8|
Structure:
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