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Target
Protein disulfide-isomerase A4
Ligand
BDBM50550835
Substrate
n/a
Meas. Tech.
ChEMBL_2028621 (CHEMBL4682779)
IC50
33100±n/a nM
Citation
 Robinson, RM; Reyes, L; Duncan, RM; Bian, H; Strobel, ED; Hyman, SL; Reitz, AB; Dolloff, NG Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor. Eur J Med Chem 186:0 (2020) [PubMed]  Article 
Target
Name:
Protein disulfide-isomerase A4
Synonyms:
5.3.4.1 | ER protein 70 | ER protein 72 | ERP70 | ERP72 | ERp-72 | Endoplasmic reticulum resident protein 70 | Endoplasmic reticulum resident protein 72 | PDIA4 | PDIA4_HUMAN | Protein disulfide-isomerase A4
Type:
PROTEIN
Mol. Mass.:
72906.88
Organism:
Homo sapiens
Description:
ChEMBL_117962
Residue:
645
Sequence:
MRPRKAFLLLLLLGLVQLLAVAGAEGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILKKGQAVDYEGSRTQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHMMDVQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL
  
Inhibitor
Name:
BDBM50550835
Synonyms:
CHEMBL4751979
Type:
Small organic molecule
Emp. Form.:
C19H23F3O2
Mol. Mass.:
340.3799
SMILES:
CCCCCCCC\C=C1/C=C(c2cc(O)c(O)cc12)C(F)(F)F |c:10|
Structure:
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