Reaction Details Report a problem with these data
Target
Cysteine proteinase falcipain 2a
Ligand
BDBM50550962
Substrate
n/a
Meas. Tech.
ChEMBL_2029197 (CHEMBL4683355)
IC50
6800±n/a nM
Citation
 Tibon, NS; Ng, CH; Cheong, SL Current progress in antimalarial pharmacotherapy and multi-target drug discovery. Eur J Med Chem 188:0 (2020) [PubMed]  Article 
Target
Name:
Cysteine proteinase falcipain 2a
Synonyms:
Cysteine protease falcipain-2
Type:
Protein
Mol. Mass.:
55996.21
Organism:
Plasmodium falciparum
Description:
Q9NBD4
Residue:
484
Sequence:
MDYNMDYAPHEVISHQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFILFYFTPNFRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50550962
Synonyms:
CHEMBL4786898
Type:
Small organic molecule
Emp. Form.:
C20H21FN6O
Mol. Mass.:
380.4187
SMILES:
Nc1ncc(NCc2ccc(CCNC(=O)c3ccc(F)cc3)cc2)c(N)n1
Structure:
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