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Target
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50552287
Substrate
n/a
Meas. Tech.
ChEMBL_2034043 (CHEMBL4688201)
IC50
23180±n/a nM
Citation
 Du, L; Wang, X; Cui, G; Xu, B Design, synthesis and biological evaluation of novel thiazole-based derivatives as human Pin1 inhibitors. Bioorg Med Chem 29:0 (2021) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
  
Inhibitor
Name:
BDBM50552287
Synonyms:
CHEMBL4742117
Type:
Small organic molecule
Emp. Form.:
C22H24N4O4S
Mol. Mass.:
440.515
SMILES:
CCO[C@@H]1CCN(C1)c1nc(NCC(O)=O)c(s1)C(=O)Nc1ccc2ccccc2c1 |r|
Structure:
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