Reaction Details Report a problem with these data
Target
Myosin light chain kinase 2, skeletal/cardiac muscle
Ligand
BDBM50345502
Substrate
n/a
Meas. Tech.
ChEMBL_2034543 (CHEMBL4688701)
IC50
5100±n/a nM
Citation
 Richter, S; Martin, R; Gutzeit, HO; Knölker, HJ In vitro and in vivo effects of inhibitors on actin and myosin. Bioorg Med Chem 30:0 (2021) [PubMed]  Article 
Target
Name:
Myosin light chain kinase 2, skeletal/cardiac muscle
Synonyms:
2.7.11.18 | MLCK2 | MYLK2 | MYLK2_RABIT | Myosin light chain kinase 2, skeletal/cardiac muscle
Type:
PROTEIN
Mol. Mass.:
65451.27
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_120139
Residue:
608
Sequence:
MATENGAVELGIQSLSTDEASKGAASEESLAAEKDPAPPDPEKGPGPSDTKQDPDPSTPKKDANTPAPEKGDVVPAQPSAGGSQGPAGEGGQVEAPAEGSAGKPAALPQQTATAEASEKKPEAEKGPSGHQDPGEPTVGKKVAEGQAAARRGSPAFLHSPSCPAIIASTEKLPAQKPLSEASELIFEGVPATPGPTEPGPAKAEGGVDLLAESQKEAGEKAPGQADQAKVQGDTSRGIEFQAVPSERPRPEVGQALCLPAREEDCFQILDDCPPPPAPFPHRIVELRTGNVSSEFSMNSKEALGGGKFGAVCTCTEKSTGLKLAAKVIKKQTPKDKEMVMLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKEQGARMSAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
  
Inhibitor
Name:
BDBM50345502
Synonyms:
CHEMBL1235156 | pentabromopseudilin
Type:
Small organic molecule
Emp. Form.:
C10H4Br5NO
Mol. Mass.:
553.665
SMILES:
Oc1c(Br)cc(Br)cc1-c1[nH]c(Br)c(Br)c1Br
Structure:
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