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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Ligand
BDBM50552477
Substrate
n/a
Meas. Tech.
ChEMBL_2034625 (CHEMBL4688783)
IC50
215300±n/a nM
Citation
 Gurusingha Arachchige, HS; Herath Mudiyanselage, PDH; VanHecke, GC; Patel, K; Cheaito, HA; Dou, QP; Ahn, YH Synthesis and evaluation of tiaprofenic acid-derived UCHL5 deubiquitinase inhibitors. Bioorg Med Chem 30:0 (2021) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Synonyms:
CGI-70 | UCH-L5 | UCH37 | UCHL5 | UCHL5_HUMAN | Ubiquitin C-terminal hydrolase UCH37 | Ubiquitin carboxyl-terminal hydrolase isozyme L5 | Ubiquitin thioesterase L5
Type:
PROTEIN
Mol. Mass.:
37597.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109575
Residue:
329
Sequence:
MTGNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPENFEKLKPVHGLIFLFKWQPGEEPAGSVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTSAKEEDAFHFVSYVPVNGRLYELDGLREGPIDLGACNQDDWISAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQLAEEEPMDTDQGNSMLSAIQSEVAKNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKAKEKQNAKKAQETK
  
Inhibitor
Name:
BDBM50552477
Synonyms:
CHEMBL4777141
Type:
Small organic molecule
Emp. Form.:
C30H24N4O4
Mol. Mass.:
504.536
SMILES:
OC(=O)c1cc(Cn2cc(nn2)-c2ccc(NCc3ccccc3)cc2)cc(c1)-c1ccccc1C(O)=O
Structure:
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