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Target
Sorbitol dehydrogenase
Ligand
BDBM50113491
Substrate
n/a
Meas. Tech.
ChEBML_201006
IC50
8±n/a nM
Citation
 Chu-Moyer, MY; Ballinger, WE; Beebe, DA; Coutcher, JB; Day, WW; Li, J; Oates, PJ; Weekly, RM SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711. Bioorg Med Chem Lett 12:1477-80 (2002) [PubMed]  Article 
Target
Name:
Sorbitol dehydrogenase
Synonyms:
DHSO_RAT | Sdh1 | Sord
Type:
PROTEIN
Mol. Mass.:
38239.67
Organism:
Rattus norvegicus
Description:
ChEMBL_223914
Residue:
357
Sequence:
MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGPMVKHLKPGDRVAIEPGVPREIDEFCKIGRYNLTPSIFFCATPPDDGNLCRFYKHSADFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPIGIVTLLVAKAMGASQVVVIDLSASRLAKAKEVGADFTIQVAKETPHDIAKKVESVLGSKPEVTIECTGAESSVQTGIYATHSGGTLVVVGMGPEMINLPLVHAAVREVDIKGVFRYCNTWPMAVSMLASKTLNVKPLVTHRFPLEKAVEAFETAKKGLGLKVMIKCDPNDQNP
  
Inhibitor
Name:
BDBM50113491
Synonyms:
1-(4-{(3S,5R)-4-[2-(1-Hydroxy-ethyl)-pyrimidin-4-yl]-3,5-dimethyl-piperazin-1-yl}-pyrimidin-2-yl)-ethanol | CHEMBL36368
Type:
Small organic molecule
Emp. Form.:
C18H26N6O2
Mol. Mass.:
358.438
SMILES:
CC(O)c1nccc(n1)N1C[C@H](C)N([C@H](C)C1)c1ccnc(n1)C(C)O
Structure:
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