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Target
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Ligand
BDBM50135599
Substrate
n/a
Meas. Tech.
ChEMBL_2046971 (CHEMBL4701670)
IC50
>50000±n/a nM
Citation
 Mitachi, K; Kansal, RG; Hevener, KE; Gillman, CD; Hussain, SM; Yun, HG; Miranda-Carboni, GA; Glazer, ES; Clemons, WM; Kurosu, M DPAGT1 Inhibitors of Capuramycin Analogues and Their Antimigratory Activities of Solid Tumors. J Med Chem 63:10855-10878 (2020) [PubMed]  Article 
Target
Name:
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Synonyms:
2.7.8.15 | DPAGT1 | DPAGT2 | G1PT | GPT | GPT_HUMAN | GlcNAc-1-P transferase | N-acetylglucosamine-1-phosphate transferase | Synonyms=DPAGT2 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Type:
PROTEIN
Mol. Mass.:
46098.54
Organism:
Homo sapiens
Description:
ChEMBL_120169
Residue:
408
Sequence:
MWAFSELPMPLLINLIVSLLGFVATVTLIPAFRGHFIAARLCGQDLNKTSRQQIPESQGVISGAVFLIILFCFIPFPFLNCFVKEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRPILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDCRDDHVFSLYFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVVGILGHFSKTMLLFFMPQVFNFLYSLPQLLHIIPCPRHRIPRLNIKTGKLEMSYSKFKTKSLSFLGTFILKVAESLQLVTVHQSETEDGEFTECNNMTLINLLLKVLGPIHERNLTLLLLLLQILGSAITFSIRYQLVRLFYDV
  
Inhibitor
Name:
BDBM50135599
Synonyms:
(4S,5S,6S)-6-{(R)-Carbamoyl-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl]-methoxy}-4,5-dihydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid ((S)-2-oxo-azepan-3-yl)-amide | CHEMBL96695
Type:
Small organic molecule
Emp. Form.:
C23H31N5O12
Mol. Mass.:
569.5185
SMILES:
CO[C@H]1[C@@H](O)[C@@H](O[C@@H]1[C@@H](O[C@H]1OC(=C[C@H](O)[C@@H]1O)C(=O)N[C@H]1CCCCNC1=O)C(N)=O)n1ccc(=O)[nH]c1=O |c:13|
Structure:
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