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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM50187658
Substrate
n/a
Meas. Tech.
ChEMBL_2048625 (CHEMBL4703324)
IC50
979±n/a nM
Citation
 Chen, LC; Huang, HL; HuangFu, WC; Yen, SC; Ngo, ST; Wu, YW; Lin, TE; Sung, TY; Lien, ST; Tseng, HJ; Pan, SL; Huang, WJ; Hsu, KC Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia. J Nat Prod 83:2967-2975 (2020) [PubMed]  Article 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM50187658
Synonyms:
4',5-dihydroxy-7-methoxy flavone | 4',5-dihydroxy-7-methoxyflavone | 5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one | 7-O-methylapigenin | CHEMBL210635 | Gonkwanin | genkwanin
Type:
Small organic molecule
Emp. Form.:
C16H12O5
Mol. Mass.:
284.2635
SMILES:
COc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)cc1
Structure:
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