Reaction Details Report a problem with these data
Target
BDNF/NT-3 growth factors receptor
Ligand
BDBM50554333
Substrate
n/a
Meas. Tech.
ChEMBL_2049101 (CHEMBL4703800)
Kd
60±n/a nM
Citation
 Chen, L; Chen, Y; Zhang, C; Jiao, B; Liang, S; Tan, Q; Chai, H; Yu, W; Qian, Y; Yang, H; Yao, W; Yu, J; Luo, Y; Plewe, M; Wang, J; Han, XR; Liu, J Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders. J Med Chem 63:14562-14575 (2020) [PubMed]  Article 
Target
Name:
BDNF/NT-3 growth factors receptor
Synonyms:
GP145-TrkB | NTRK1/NTRK2 | NTRK2 | NTRK2_HUMAN | Neurotrophic tyrosine kinase receptor type 2 | TRKB | Trk-B | TrkB tyrosine kinase | Tropomyosin-related kinase B | Tropomyosin-related kinase B (TRKB) | Tyrosine kinase receptor B (Trk-B)
Type:
Enzyme
Mol. Mass.:
91996.87
Organism:
Homo sapiens (Human)
Description:
Q16620
Residue:
822
Sequence:
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
  
Inhibitor
Name:
BDBM50554333
Synonyms:
CHEMBL4790500
Type:
Small organic molecule
Emp. Form.:
C44H45FN10O6
Mol. Mass.:
828.8899
SMILES:
CN1C(=O)CCC(N2C(=O)c3cccc(NCCOCCC(=O)N4CCN(CC4)c4cccc(n4)-c4cnc5ccc(nn45)N4CCC[C@@H]4c4cccc(F)c4)c3C2=O)C1=O |r|
Structure:
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