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Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Ligand
BDBM50115463
Substrate
n/a
Meas. Tech.
ChEMBL_212265 (CHEMBL878971)
IC50
1600±n/a nM
Citation
 Kline, T; Andersen, NH; Harwood, EA; Bowman, J; Malanda, A; Endsley, S; Erwin, AL; Doyle, M; Fong, S; Harris, AL; Mendelsohn, B; Mdluli, K; Raetz, CR; Stover, CK; Witte, PR; Yabannavar, A; Zhu, S Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC. J Med Chem 45:3112-29 (2002) [PubMed]  Article 
Target
Name:
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Synonyms:
LPXC_PSEAE | Protein envA | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-acyl-GlcNAc deacetylase | UDP-3-O-acyl-GlcNAc deacetylase (LpxC) | envA | lpxC
Type:
Enzyme
Mol. Mass.:
33428.15
Organism:
Pseudomonas aeruginosa
Description:
P47205
Residue:
303
Sequence:
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRPAAAV
  
Inhibitor
Name:
BDBM50115463
Synonyms:
2-(5-Fluoro-1H-indol-2-yl)-4,5-dihydro-oxazole-4-carboxylic acid hydroxyamide | CHEMBL324440
Type:
Small organic molecule
Emp. Form.:
C12H10FN3O3
Mol. Mass.:
263.2245
SMILES:
ONC(=O)C1COC(=N1)c1cc2cc(F)ccc2[nH]1 |c:7|
Structure:
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