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Target
Delta-type opioid receptor
Ligand
BDBM50554769
Substrate
n/a
Meas. Tech.
ChEMBL_2050544 (CHEMBL4705243)
EC50
1296±n/a nM
Citation
 Faouzi, A; Uprety, R; Gomes, I; Massaly, N; Keresztes, AI; Le Rouzic, V; Gupta, A; Zhang, T; Yoon, HJ; Ansonoff, M; Allaoa, A; Pan, YX; Pintar, J; Morón, JA; Streicher, JM; Devi, LA; Majumdar, S Synthesis and Pharmacology of a Novel ?-? Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template. J Med Chem 63:13618-13637 (2020) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50554769
Synonyms:
CHEMBL4788377
Type:
Small organic molecule
Emp. Form.:
C31H37N3O3
Mol. Mass.:
499.6438
SMILES:
CCC(=O)N(Cc1ccccc1)C1(CCN(CCc2ccccc2)CC1)C(=O)Nc1ccc(OC)cc1
Structure:
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