Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM50115618
Substrate
n/a
Meas. Tech.
ChEMBL_35527 (CHEMBL649553)
Ki
20±n/a nM
Citation
 Powers, RA; Shoichet, BK Structure-based approach for binding site identification on AmpC beta-lactamase. J Med Chem 45:3222-34 (2002) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ECOLI | Beta-lactamase | Beta-lactamase (AmpC) | Beta-lactamase AmpC | Cephalosporinase | Escherichia coli K-12 | ampA | ampC
Type:
Protien
Mol. Mass.:
41561.62
Organism:
Escherichia coli
Description:
P00811
Residue:
377
Sequence:
MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ
  
Inhibitor
Name:
BDBM50115618
Synonyms:
2-[(2-Amino-thiazol-4-yl)-(dihydroxyboranylmethyl-carbamoyl)-methyleneaminooxy]-2-methyl-propionic acid | CHEMBL324887
Type:
Small organic molecule
Emp. Form.:
C10H14BN4O6S
Mol. Mass.:
329.118
SMILES:
CC(C)(O\N=C(\C(=O)NCB(O)O)c1csc(N)n1)C([O-])=O
Structure:
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