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Target
Histone-lysine N-methyltransferase NSD3
Ligand
BDBM50555100
Substrate
n/a
Meas. Tech.
ChEMBL_2051300 (CHEMBL4705999)
Kd
300000±n/a nM
Citation
 Jahnke, W; Erlanson, DA; de Esch, IJP; Johnson, CN; Mortenson, PN; Ochi, Y; Urushima, T Fragment-to-Lead Medicinal Chemistry Publications in 2019. J Med Chem 63:15494-15507 (2020) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase NSD3
Synonyms:
NSD3 | NSD3_HUMAN | Nuclear SET domain-containing protein 3 (NSD3) | WHSC1L1
Type:
Protein
Mol. Mass.:
161657.70
Organism:
Homo sapiens (Human)
Description:
Q9BZ95
Residue:
1437
Sequence:
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVKE
  
Inhibitor
Name:
BDBM50555100
Synonyms:
CHEMBL4749457
Type:
Small organic molecule
Emp. Form.:
C13H12N4O
Mol. Mass.:
240.2606
SMILES:
Cc1noc(C)c1-c1[nH]ncc1-c1ccncc1 |(19.1,-12.78,;17.77,-13.55,;16.37,-12.93,;15.34,-14.08,;16.11,-15.41,;15.49,-16.82,;17.62,-15.08,;18.78,-16.11,;20.28,-15.78,;21.06,-17.11,;20.03,-18.26,;18.62,-17.64,;17.29,-18.42,;15.96,-17.65,;14.63,-18.42,;14.62,-19.97,;15.96,-20.74,;17.3,-19.97,)|
Structure:
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