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Target
GTPase KRas
Ligand
BDBM50549225
Substrate
n/a
Meas. Tech.
ChEMBL_2051302 (CHEMBL4706001)
Kd
750±n/a nM
Citation
 Jahnke, W; Erlanson, DA; de Esch, IJP; Johnson, CN; Mortenson, PN; Ochi, Y; Urushima, T Fragment-to-Lead Medicinal Chemistry Publications in 2019. J Med Chem 63:15494-15507 (2020) [PubMed]  Article 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50549225
Synonyms:
CHEMBL4750445
Type:
Small organic molecule
Emp. Form.:
C31H28N6O2
Mol. Mass.:
516.593
SMILES:
Cn1cnc(Cn2ccc3ccc(CNCc4[nH]c5ccccc5c4[C@H]4NC(=O)c5ccc(O)cc45)cc23)c1 |r|
Structure:
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