Reaction Details Report a problem with these data
Target
Glutamate receptor ionotropic, kainate 3
Ligand
BDBM50116040
Substrate
n/a
Meas. Tech.
ChEBML_72855
Ki
46±n/a nM
Citation
 Lubisch, W; Behl, B; Henn, C; Hofmann, HP; Reeb, J; Regner, F; Vierling, M Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5. Bioorg Med Chem Lett 12:2113-6 (2002) [PubMed]  Article 
Target
Name:
Glutamate receptor ionotropic, kainate 3
Synonyms:
EAA5 | Excitatory amino acid receptor 5 | GLUR7 | GRIK3 | GRIK3_HUMAN | GluR-7 | Glutamate receptor 7 | Glutamate receptor ionotropic kainate | Glutamate receptor ionotropic kainate 3 | Glutamate receptor, ionotropic kainate 3 | Glutamate-Kainate 7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
104046.44
Organism:
Homo sapiens (Human)
Description:
Glutamate-Kainate 7 0 HUMAN::Q13003
Residue:
919
Sequence:
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMACSTSLAPVFP
  
Inhibitor
Name:
BDBM50116040
Synonyms:
(7-{3-[3-(4-Nitro-phenyl)-ureidomethyl]-pyrrol-1-yl}-2,3-dioxo-6-trifluoromethyl-3,4-dihydro-2H-quinoxalin-1-yl)-acetic acid | CHEMBL13076
Type:
Small organic molecule
Emp. Form.:
C23H17F3N6O7
Mol. Mass.:
546.4123
SMILES:
OC(=O)Cn1c2cc(c(cc2[nH]c(=O)c1=O)C(F)(F)F)-n1ccc(CNC(=O)Nc2ccc(cc2)[N+]([O-])=O)c1
Structure:
Search PDB for entries with ligand similarity: