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Target
Serine/threonine-protein kinase PAK 1
Ligand
BDBM50555983
Substrate
n/a
Meas. Tech.
ChEMBL_2054467 (CHEMBL4709468)
IC50
21±n/a nM
Citation
 Zhang, M; Fang, X; Wang, C; Hua, Y; Huang, C; Wang, M; Zhu, L; Wang, Z; Gao, Y; Zhang, T; Liu, H; Zhang, Y; Lu, S; Lu, T; Chen, Y; Li, H Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities. Eur J Med Chem 203:0 (2020) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PAK 1
Synonyms:
2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK
Type:
n/a
Mol. Mass.:
60640.15
Organism:
Homo sapiens (Human)
Description:
Q13153
Residue:
545
Sequence:
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH
  
Inhibitor
Name:
BDBM50555983
Synonyms:
CHEMBL4787358
Type:
Small organic molecule
Emp. Form.:
C27H22ClN5O2
Mol. Mass.:
483.949
SMILES:
Cc1cccn(-c2ccc(c(Cl)c2)-c2ccc3c(n[nH]c3c2)C(=O)NCCc2ccncc2)c1=O
Structure:
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