Reaction Details Report a problem with these data
Target
Folate receptor beta
Ligand
BDBM50557564
Substrate
n/a
Meas. Tech.
ChEMBL_2059598 (CHEMBL4714599)
IC50
1.2±n/a nM
Citation
Wallace-Povirk, A; Tong, N; Wong-Roushar, J; O'Connor, C; Zhou, X; Hou, Z; Bao, X; Garcia, GE; Li, J; Kim, S; Dann, CE; Matherly, LH; Gangjee, A Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors. Bioorg Med Chem 37:0 (2021) [PubMed] Article
More Info.:
Target
Name:
Folate receptor beta
Synonyms:
FBP | FOLR2 | FOLR2_HUMAN | FR-beta | Folate receptor 2 | Folate receptor beta | Folate receptor, fetal/placental | Placental folate-binding protein
Type:
PROTEIN
Mol. Mass.:
29286.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_20077
Residue:
255
Sequence:
MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGGLLLSLALMLQLWLLG