Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50118766
Substrate
n/a
Meas. Tech.
ChEMBL_207125 (CHEMBL805109)
pH
7±n/a
Ki
17000±n/a nM
Comments
extracted
Citation
 Andersen, HS; Olsen, OH; Iversen, LF; Sørensen, AL; Mortensen, SB; Christensen, MS; Branner, S; Hansen, TK; Lau, JF; Jeppesen, L; Moran, EJ; Su, J; Bakir, F; Judge, L; Shahbaz, M; Collins, T; Vo, T; Newman, MJ; Ripka, WC; Møller, NP Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. J Med Chem 45:4443-59 (2002) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50118766
Synonyms:
6-[2-(2-Benzyloxy-phenyl)-ethyl]-2-(oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid | CHEMBL344368
Type:
Small organic molecule
Emp. Form.:
C25H24N2O6S
Mol. Mass.:
480.533
SMILES:
OC(=O)C(=O)Nc1sc2CN(CCc3ccccc3OCc3ccccc3)CCc2c1C(O)=O
Structure:
Search PDB for entries with ligand similarity: