Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50119308
Substrate
n/a
Meas. Tech.
ChEMBL_47424 (CHEMBL662611)
Ki
4550±n/a nM
Citation
 Huang, L; Ellman, JA General solid-phase method to prepare novel cyclic ketone inhibitors of the cysteine protease cruzain. Bioorg Med Chem Lett 12:2993-6 (2002) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50119308
Synonyms:
CHEMBL105708 | [(S)-1-(1-Isobutyl-2,5-dioxo-piperidin-4-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C26H31N3O5
Mol. Mass.:
465.5414
SMILES:
CC(C)CN1CC(=O)C(CC1=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
Structure:
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