Reaction Details Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50119484
Substrate
n/a
Meas. Tech.
ChEMBL_52891 (CHEMBL872485)
Ki
>50000±n/a nM
Citation
Haque, TS; Tadesse, S; Marcinkeviciene, J; Rogers, MJ; Sizemore, C; Kopcho, LM; Amsler, K; Ecret, LD; Zhan, DL; Hobbs, F; Slee, A; Trainor, GL; Stern, AM; Copeland, RA; Combs, AP Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase. J Med Chem 45:4669-78 (2002) [PubMed] Article
More Info.:
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Inhibitor
Name:
BDBM50119484
Synonyms:
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-{[4-(pyrrolidine-1-carbonyl)-phenyl]-amide} 3-[(tetrahydro-furan-2-ylmethyl)-amide] | CHEMBL442030
Type:
Small organic molecule
Emp. Form.:
C28H31N5O5
Mol. Mass.:
517.5762
SMILES:
COc1ccc(cc1)-n1nc(cc1C(=O)Nc1ccc(cc1)C(=O)N1CCCC1)C(=O)NCC1CCCO1