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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50557933
Substrate
n/a
Meas. Tech.
ChEMBL_2060789 (CHEMBL4716042)
Ki
0.039811±n/a nM
Citation
 Gruber, CG; Pegoli, A; Müller, C; Grätz, L; She, X; Keller, M Differently fluorescence-labelled dibenzodiazepinone-type muscarinic acetylcholine receptor ligands with high M RSC Med Chem 11:823-832 (2020) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50557933
Synonyms:
CHEMBL4634333
Type:
Small organic molecule
Emp. Form.:
C59H71N7O7S2
Mol. Mass.:
1054.368
SMILES:
Cc1scc2c1N(C(=O)CN1CCN(CCCCCCCCCCNC(=O)Cc3ccc4N5CCC6OC7CC[N+]8=C(C7=CC6=C5C(C)(C)c4c3)C(C)(C)c3cc(ccc83)S([O-])(=O)=O)CC1)c1ccccc1NC2=O |c:41,44,47|
Structure:
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