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Target
Endothelin-1 receptor
Ligand
BDBM50119659
Substrate
n/a
Meas. Tech.
ChEBML_65490
IC50
2.2±n/a nM
Citation
 Niiyama, K; Takahashi, H; Nagase, T; Kojima, H; Amano, Y; Katsuki, K; Yamakawa, T; Ozaki, S; Ihara, M; Yano, M; Fukuroda, T; Nishikibe, M; Ishikawa, K Structure-Activity relationships of 2-substituted 5,7-Diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acids as a novel class of endothelin receptor antagonists. Bioorg Med Chem Lett 12:3041-5 (2002) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Homo sapiens (Human)
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50119659
Synonyms:
(R)-5-Benzo[1,3]dioxol-5-yl-7-(4-methoxy-phenyl)-2-pyrrolidin-1-yl-6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid | CHEMBL102173
Type:
Small organic molecule
Emp. Form.:
C27H26N2O5
Mol. Mass.:
458.5057
SMILES:
COc1ccc(cc1)[C@H]1[C@@H]([C@H](c2ccc(nc12)N1CCCC1)c1ccc2OCOc2c1)C(O)=O
Structure:
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