Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM50558854
Substrate
n/a
Meas. Tech.
ChEMBL_2065940 (CHEMBL4721193)
IC50
14±n/a nM
Citation
 D de Araujo, A; Lim, J; Wu, KC; Xiang, Y; Good, AC; Skerlj, R; Fairlie, DP Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl-1 Proteins. J Med Chem 61:2962-2972 (2018) [PubMed]  Article 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM50558854
Synonyms:
CHEMBL4755711
Type:
Small organic molecule
Emp. Form.:
C120H186N34O31
Mol. Mass.:
2600.97
SMILES:
[H][C@]1(NC(=O)[C@](C)(CCC\C=C\CCC[C@](C)(NC(=O)[C@H](CC(O)=O)NC(=O)CNC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)C(CNC(=O)C=C)NC(=O)[C@@H](NC(C)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC |r,t:10|
Structure:
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