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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50559037
Substrate
n/a
Meas. Tech.
ChEMBL_2067515 (CHEMBL4722768)
Kd
181000±n/a nM
Citation
 Liu, Q; Miao, Y; Wang, X; Lv, G; Peng, Y; Li, K; Li, M; Qiu, L; Lin, J Structure-based virtual screening and biological evaluation of novel non-bisphosphonate farnesyl pyrophosphate synthase inhibitors. Eur J Med Chem 186:0 (2020) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
(2E,6E)-farnesyl diphosphate synthase | 2.5.1.1 | 2.5.1.10 | CR 39 | Cholesterol-regulated 39 kDa protein | Dimethylallyltranstransferase | FPP synthase | FPPS_RAT | FPS | Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase | Fdps | Geranyltranstransferase
Type:
PROTEIN
Mol. Mass.:
40823.17
Organism:
Rattus norvegicus
Description:
ChEMBL_103143
Residue:
353
Sequence:
MNGDQKLDVHNQEKQNFIQHFSQIVKVLTEDELGHPEKGDAITRIKEVLEYNTVGGKYNRGLTVVQTFQELVEPRKQDAESLQRALTVGWCVELLQAFFLVLDDIMDSSYTRRGQICWYQKPGIGLDAINDALLLEAAIYRLLKFYCREQPYYLNLLELFLQSSYQTEIGQTLDLITAPQGQVDLGRYTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANALKILLEMGEFFQIQDDYLDLFGDPSVTGKVGTDIQDNKCSWLVVQCLLRATPQQRQILEENYGQKDPEKVARVKALYEELDLRSVFFKYEEDSYNRLKSLIEQCSAPLPPSIFLELANKIYKRRK
  
Inhibitor
Name:
BDBM50559037
Synonyms:
CHEMBL4753538
Type:
Small organic molecule
Emp. Form.:
C19H16N2O5
Mol. Mass.:
352.3407
SMILES:
OC1(CC(=O)CC2(O)C(=O)Nc3ccccc23)C(=O)Nc2ccccc12
Structure:
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