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Target
Metabotropic glutamate receptor 2
Ligand
BDBM50559795
Substrate
n/a
Meas. Tech.
ChEMBL_2070364 (CHEMBL4725898)
EC50
62±n/a nM
Citation
 Fulton, MG; Loch, MT; Rodriguez, AL; Lin, X; Javitch, JA; Conn, PJ; Niswender, CM; Lindsley, CW Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
GRM2_RAT | Gprc1b | Grm2 | Mglur2
Type:
PROTEIN
Mol. Mass.:
95786.41
Organism:
Rattus norvegicus
Description:
ChEMBL_105034
Residue:
872
Sequence:
MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
  
Inhibitor
Name:
BDBM50559795
Synonyms:
CHEMBL4779278
Type:
Small organic molecule
Emp. Form.:
C30H30O5
Mol. Mass.:
470.5562
SMILES:
Cc1c2C(=O)C(Cc2cc(OCc2cccc(c2)-c2ccc(O)c(c2)C(O)=O)c1C)C1CCCC1
Structure:
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