Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Metabotropic glutamate receptor 4
Ligand
BDBM50559788
Substrate
n/a
Meas. Tech.
ChEMBL_2070366 (CHEMBL4725900)
EC50
35±n/a nM
Citation
Fulton, MG; Loch, MT; Rodriguez, AL; Lin, X; Javitch, JA; Conn, PJ; Niswender, CM; Lindsley, CW Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu Bioorg Med Chem Lett 30:0 (2020) [PubMed] Article More Info.:
Target
Name:
Metabotropic glutamate receptor 4
Synonyms:
GRM4_RAT | Gprc1d | Grm4 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 4 (mGlu4) | Mglur4 | mGlu4 | metabotropic glutamate 4 | metabotropic glutamate 4a
Type:
Enzyme
Mol. Mass.:
101849.79
Organism:
Rattus norvegicus (Rat)
Description:
P31423
Residue:
912
Sequence:
MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI
Inhibitor
Name:
BDBM50559788
Synonyms:
CHEMBL4777845
Type:
Small organic molecule
Emp. Form.:
C61H62ClN6NaO12
Mol. Mass.:
1129.621
SMILES:
[Na;v0+].[#6]-[#8]-c1cc(-[#7]-[#6](=O)-c2ccccn2)ccc1-[#7]-[#6](=O)-c1ccc(-[#7]-[#6](=O)-[#6]-[#8]-[#6]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#8]-c2ccc(cc2-[#6](-[#8-])=O)-c2cccc(-[#6]-[#8]-c3cc4-[#6]-[#6](-[#6]-5-[#6]-[#6]-[#6]-[#6]-5)-[#6](=O)-c4c(-[#6])c3-[#6])c2)cc1Cl
Structure:
