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Target
Follicle-stimulating hormone receptor
Ligand
BDBM50559935
Substrate
n/a
Meas. Tech.
ChEMBL_2070728 (CHEMBL4726262)
IC50
8030±n/a nM
Citation
 Paciaroni, NG; Norwood, VM; Ratnayake, R; Luesch, H; Huigens, RW Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Follicle-stimulating hormone receptor
Synonyms:
FSH-R | FSHR | FSHR_HUMAN | Follicle stimulating hormone receptor | Follicle-stimulating hormone receptor | Follitropin receptor | LGR1
Type:
PROTEIN
Mol. Mass.:
78273.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1351769
Residue:
695
Sequence:
MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTNGSTYILVPLSHLAQN
  
Inhibitor
Name:
BDBM50559935
Synonyms:
CHEMBL4780505
Type:
Small organic molecule
Emp. Form.:
C29H32BrN3O4
Mol. Mass.:
566.486
SMILES:
[H][C@@]12CC[C@H](O)[C@H](C(=O)OC)[C@@]1([H])C[C@@H](OCc1ccc(Br)cc1)c1[nH]c3ccccc3c1CCN(C2)C#N |r|
Structure:
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